Aberrant Lymphatic Drainage of Primary Invasive Lobular Carcinoma with Concurrent Primary Lung Adenocarcinoma: A Case Report
Keywords:Lobular carcinoma, Adenocarcinoma of the lung
Background: Lymphatic spread of breast cancer is currently well understood and can be assessed in breast cancer patients through the use of lymphatic mapping with sentinel node biopsy, CT, PET.
The Case: Here we present a case report of a 73-year-old female with two distinct primary carcinomas, right-sided invasive lobular carcinoma of the breast and left-sided adenocarcinoma of the lung. We also discuss the predictable and unpredictable lymphatic drainage of the lobular carcinoma, including ipsilateral drainage to the axillary chain and suspected contralateral hilar and mediastinal lymph node metastasis.
Conclusion: The unique lymphatic spread of breast cancer, in this case, emphasizes the use of lymphatic mapping for the staging of disease and staining biopsied tissue samples for tumor markers to guide treatment. Additional anatomic research in this patient or supporting reported cases are needed to determine the frequency and cause of aberrant lymphatic drainage of primary invasive lobular carcinoma of the breast.
Cocquyt V, Van Belle S. Lobular carcinoma in situ and invasive lobular cancer of the breast.
Curr Opin Obstet Gyn. 2005 Feb;17(1):55-60.
McCart Reed AE, Kutasovic JR, Lakhani SR, Simpson PT. Invasive lobular carcinoma of the
breast: morphology, biomarkers and 'omics. Breast Cancer Res. 2015;17(1):12.
Arpino G, Bardou VJ, Clark GM, Elledge RM. Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome. Breast Cancer Res. 2004;6(3):R149–R156.
Osaku T, Ogata H, Magoshi S, et al. Metastatic nonpalpable invasive lobular breast carcinoma presenting as rectal stenosis: a case report. J Med Case Rep. 2015;9:88.
Aukema TS, Straver ME, Vrancken Peeters MJTFD, et al. Detection of extra-axillary lymph node involvement with FDG PET/CT in patients with stage II-III breast cancer. European Journal of Cancer. 2010;46(18):3205-3210.
Burns Z, Omar L, Compton L, Hayes J, Sahoo S, Merchant K. Lymphangitic spread of invasive lobular carcinoma to the contralateral breast. Clin Imaging. 2019 Nov;58:187-190.
Popper HH. Progression and metastasis of lung cancer. Cancer Metastasis Rev. 2016 Mar;35(1):75-91.
Sharma A, Fidias P, Hayman LA, Loomis SL, Taber KH, Aquino SL. Patterns of Lymphadenopathy in Thoracic Malignancies. RadioGraphics. 2004;24(2):419-434.
Estourgie SH, Nieweg OE, Olmos RA, Rutgers EJ, Kroon BB. Lymphatic drainage patterns from the breast. Annals of Surgery. 2004;239(2), 232–237.
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